8 1 2 6 75 45

8 1 2 6 75 45



NTIS Reports




Chlorodifluoromethane (Freon 22)
CAS No. 75-45-6

















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Adverse Effects

Abstracts

ACTIVITY:

Insecticide, Fungicide, Propellant, EPA List 2 Inert
(Halogenated organic)

Structure:

The following is a long list of studies available from the National Technical Information Service

Table 1: Mainly Health Studies
Table 2: All other



Table 1.

Health Studies available from The National Technical Information Service(NTIS)





Order from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at [email protected] NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.

These studies were cited at Toxline at Toxnet on Dec 10, 2004.

Order No. Title / Date Keywords CAS Numbers


NTIS/OTS0520117

EPA/OTS; Doc #86-890000973S

2000



LETTER CONCERNING SOME TYPE ILLNESS THAT HAVE AFFECTED AREA EMPLOYEES

CONFIDENTIAL
SANITIZED


HEALTH EFFECTS
EPIDEMIOLOGY
MAMMALS
HUMANS
INHALATION

75-45-6


NTIS/OTS0574011

EPA/OTS; Doc #88000000099

2000

– INITIAL SUBMISSION: LETTER FROM ELF ATOCHEM NORTH AMERICA, INC TO USEPA
REPORTING FATALITY DUE TO MISUSE OF CHLORODIFLUOROMETHANE, DATED
02-15-00

ELF ATOCHEM NA INC


CHLORODIFLUOROMETHANE
HEALTH EFFECTS
CASE REPORT
MAMMALS
HUMANS

75-45-6


NTIS/OTS0520491

EPA/OTS; Doc #86-890000443

2000

– CHLORODIFLUOROMETHANE (CFC 22):
LONG TERM INHALATION
STUDY IN THE RAT WITH ATTACHMENTS


CENTRAL TOXICOL LAB

IMPERIAL CHEMIAL INDUS


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION

75-45-6


NTIS/OTS0520132

EPA/OTS; Doc #86-890000988S

2000



LETTER FROM E I DUPONT DE NEMOURS & COMPANY REGARDING DATA AND INFORMATION ON
FREON 22
AND FREON 12
(SANITIZED)

E I DUPONT DE NEMOURS & CO
FREON 22 (75-45-6)

HEALTH EFFECTS
INDUSTRIAL HYGIENE
75-45-6



75-71-8


NTIS/OTS0520490

EPA/OTS; Doc #86-890000442

2000

– CHLORODIFLUOROMETHANE (CFC 22):
LONG TERM INHALATION
STUDY IN THE MOUSE WITH ATTACHMENTS

CENTRAL TOXICOL LAB


IMPERIAL CHEMICAL INDUS


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
MICE
INHALATION

75-45-6


NTIS/OTS0520116

EPA/OTS; Doc #86-890000972S

2000

– TOXICITY OF REFRIGERANTS (SANITIZED)
Acute inhalation toxicity was evaluated in guinea pigs (sex, strain, and number not reported) receiving chlorodifluoromethane at concentration levels of 4.4% (v/v) for 6 hours and 5.2 or 20.3% (v/v) for 2 hours. No mortalities were reported. Slight labored breathing, and shivering were noted in 1 animal of the 4.4% group. At 5.2% there were occasional chewing movements, partially closed eyes, irregular breathing, shaking of heads, and rubbing of noses with feet. All animals at this exposure level recovered (time of recovery not reported). At 20.3% animals showed inability to stand, convulsive leg movements, tremors, lacrimation,
nasal discharge, and audible breathing. All recovered within 1 day of exposure. Gross necropsy findings were not reported.


SANITIZED

HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
GUINEA PIGS
INHALATION



75-45-6



NTIS/OTS0520493

EPA/OTS; Doc #86-890000445

2000

– ARCTON 22:
METABOLISM STUDY IN VIVO IN RATS AND IN VITRO

WITH ATTACHMENTS


CENTRAL TOXICOL LAB

I

MPERIAL CHEMIAL INDUS
ARCTON 22 (75-45-6)


HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
INHALATION
IN VITRO

75-45-6


NTIS/OTS0520496

EPA/OTS; Doc #86-890000448

2000

– ARCTON 22: SECOND
DOMINANT LETHAL STUDY
IN THE MOUSE WITH ATTACHMENTS


CENTRAL TOXICOL LAB

The dominant lethal effects of chlorodifluoromethane were evaluated in 6 groups of 20 fertile male CD-1 mice exposed by inhalation to chlorodifluoromethane (Arcton 22) at nominal concentrations of 10, 100, 500, 1000, 10000, or 50000 ppm for 6 hours/day, for 5 consecutive days. A group of 40 male mice served as the untreated control. A group of 20 mice injected once intraperitoneally with 200 mg/kg cyclophosphamide served as the positive control. Mating followed the final treatment period. Each male mouse in each treatment group was paired with 2 virgin female 10-week old mice, during 8 consecutive 4-day mating periods, commencing at 7-day intervals.
A significant reduction in the percentage of females which became pregnant occurred in the 5th mating period in females mated to males in the 10,000 and 50,000 ppm exposure groups.
The number of successful matings per male was statistically significantly reduced in the 10 ppm exposure group in weeks 4 and 7, in the 10,000 ppm group in week 5, and in the 50,000 ppm group in weeks 1, 5, and 7.
The time of sacrifice of the mated females was not reported.
The number of implantations per pregnancy was significantly reduced in females mated to males in the 100 ppm exposure group (week 4), in the 500 ppm group (week 6), and in the 1000 ppm exposure group (week 5). All treated groups except the 10,000 ppm group had a significant increase in early deaths. Late deaths were significantly increased in pups of females mated in week 4 (100, 1000, and 50000 ppm) and in week 7 (50000 ppm).

Keywords:

IMPERIAL CHEMICAL INDUS

ARCTON 22 (75-45-6)

HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
MICE
INHALATION

75-45-6

NTIS/OTS0514917

EPA/OTS; Doc #86-870001015

2000

CARDIAC
SENSITIZATION IN DOGS

E.I. DUPONT DE NEMOURS & CO

PROPANE (74-98-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION
74-98-6

75-00-3

75-37-6

75-45-6


75-68-3

76-15-3

115-10-6

127-18-4


NTIS/OTS0520484

EPA/OTS; Doc #86-890000436

2000

– FLUOROCHLOROCARBONS: A SUMMARY REPORT OF THE FINDINGS FROM
SHORT-TERM PREDICTIVE TESTS AND LONG-TERM RAT CARCINOGENICITY

STUDIES WITH ATTACHMENTS


CENTRAL TOXICOL LAB

IMPERIAL CHEMICAL INDUS

CHLOROFLUOROMETHANE (593-70-4)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
ORAL
GAVAGE

75-45-6

593-70-4



NTIS/OTS0520485

EPA/OTS; Doc #86-890000437

2000


MUTAGENICITY TESTING
WITH SALMONELLA TYPHIMURIUM STRAINS ON PLATES, OF GASES, LIQUIDS AND SOLIDS FOR IMPERIAL CHEMICAL INDUSTRIES LIMITIED WITH ATTACHMENTS


CENTRAL TOXICOL LAB



IMPERIAL CHEMICAL INDUS

CARBON TETRACHLORIDE (56-23-5)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
56-23-5

68-12-2

75-01-4

75-09-2

75-10-5

75-43-4

75-45-6


75-68-3

75-88-7

96-45-7

127-19-5

420-46-2

593-70-4

680-31-9


NTIS/OTS0520492

EPA/OTS; Doc #86-890000444

2000

– ARCTON 22:
A SECOND CYTOGENETIC STUDY
IN THE RAT WITH ATTACHMENTS



CENTRAL TOXICOL LAB

The frequency of chromosome aberrations was determined in bone marrow cells of Wistar-derived male rats exposed by inhalation to chlorodifluoromethane (Arcton 22) for 6 hours/day over 5 consecutive days. Five groups of 12 male rats (150 to 200g; 8 to 10 weeks old) were exposed to nominal concentrations of 0, 10, 100, 500, and 1000 ppm of Arcton 22. A positive control group of 12 rats was exposed to 4000 ppm benzene. Cell division was arrested 4 hours after the final exposure with an intraperitoneal injection of colchicine (3 mg/kg). Rats were sacrificed 6 hours after the final exposure, and fifty cells from each animal were examined. The proportion of cells with any abnormality, and the proportion of cells with any abnormality except gaps, were compared with the negative control group using ANOVA (data were arcsine-transformed). The proportion of animals with any abnormality except gaps was compared with the negative control using Fisher’s exact test. There was an inverse dose-response relationship between treated groups.
The mean percentage of bone marrow cells with chromosomal abnormalities (other than gaps) was significantly different in the group nominally exposed to 10 ppm, but not at higher concentrations. The percentage of rats with chromosomal abnormalities (except gaps) was elevated in groups exposed to all but the highest concentration.


MPERIAL CHEMICAL INDUS
ARCTON 22 (75-45-6)


HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS


MAMMALS
RATS
INHALATION


75-45-6


NTIS/OTS0520494


EPA/OTS; Doc #86-890000446

2000

– ARCTON 22:
CYTOGENETIC STUDY IN THE RAT
WITH ATTACHMENTS


CENTRAL TOXICOL LAB

IMPERIAL CHEMICAL INDUS


ARCTON 22 (75-45-6)

HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS


MAMMALS
RATS
INHALATION

75-45-6


NTIS/OTS0540606

EPA/OTS; Doc #88-920004258

1992

– INITIAL SUBMISSION:
EMBRYOTOXIC AND TERATOGENIC STUDIES IN RATS
WITH INHALED CHLORODIFLUOROMETHANE WITH COVER LETTER DATED
06-15-92
AND ATTACHMENTS

HASKELL LABORATORY

Chlorodifluoromethane (FC-22) was evaluated for embyotoxicity and teratogenicity in groups of 40 pregnant Charles River rats exposed to the test substance by inhalation at concentrations of 0, 0.05, 0.10, and 2.00% on days 6-15 of gestation. No clinical signs of toxicity were observed in maternal animals. The number of implantations, early and late resorptions, and number of live fetuses per litter were unaffected.
There was a sporadic appearance of major malformations of the eye in all test groups.
The increased incidence of eye defects was not statistically significant. Authors believe that the test substance may have interacted with the genetic make-up of affected fetuses and caused the increased expressivity of a mutant gene.

The authors considered the test substance to be a mutagen under the conditions of this study.

• Note from FAN: Anophthalmic
definition: Absence of an eye(s).  It can be a congenital (born without) or an acquired condition (surgically removed).

Keywords:

E I DUPONT DE NEMOURS & CO

CHLORODIFLUOROMETHANE
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION


75-45-6


NTIS/OTS0545682

EPA/OTS; Doc #88-920007428

1992


ANOPHTHALMIA AND MICROPHTALMIA
WITH COVER LETTER DATED
08-28-92


HUNTINGDON RES CNTR

ICI AMERS INC
ARCTON 22



HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION

75-45-6


NTIS/OTS0555242

EPA/OTS; Doc #88-920008820

1992

– INITIAL SUBMISSION:
EMBRYTOXICITY AND TERATOGENIC STUDIES IN RATS
WITH INHALED CHLOROFLUOROMETHANE (FC-22) WITH COVER LETTER DATED
09/02/92


HASKELL LABORATORY


E I DUPONT DE NEMOURS & CO

CHLORODIFLUOROMETHANE
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
REPRODUCTION/FERTILITY
EFFECTS
TERATOGENICITY

75-45-6


NTIS/OTS0538018

EPA/OTS; Doc #88-920001373


1992

– INITIAL SUBMISSION: REPORT COVER LETTER REGARDING
HUMAN LIVER TEST ABNORMALITIES
IN RELATION TO ACETONE, 1,1,1 TRICHLOROETHANE, FREON AND OTHER SOLVENTS DATED 031192

HONEYWELL INC


1,1,1 TRICHLOROETHANE
HEALTH EFFECTS
CASE REPORT
67-64-1

71-55-6

75-45-6


NTIS/OTS0545690

EPA/OTS; Doc #88-920007436

1992

– INITIAL SUBMISSION: ARCTON 22:
CYTOGENIC STUDY
IN THE RAT WITH COVER LETTER DATED
08-28-92



IMPERIAL CHEM INDUS LTD



ICI AMERS INC
CHLORODIFLUOROMETHANE


HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS


MAMMALS
RATS
INHALATION

75-45-6


NTIS/OTS0545700

EPA/OTS; Doc #88-920007446

1992

– INITIAL SUBMISSION: ARCTON 22:
A SECOND CYTOGENETIC STUDY
IN THE RAT WITH COVER LETTER DATED
08-28-92


IMPERIAL CHEM INDUS LTD


ICI AMERS INC

ARCTON 22
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS


MAMMALS
RATS
INHALATION

75-45-6



NTIS/OTS0545691


EPA/OTS; Doc #88-920007437

1992

– INITIAL SUBMISSION: ARCTON 22:
SECOND DOMINANT LETHAL DOSE STUDY IN THE MOUSE & DOMINANT LETHAL STUDY IN THE MOUSE WITH COVER LETTER DATED
08-28-92


IMPERIAL CHEM INDUS LTD

Keywords:

ICI AMERS INC

ARCTON 22
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS


MAMMALS
MICE
INHALATION

75-45-6


NTIS/PB92-193697


14p

1992




Fatal Accident Circumstances and Epidemiology (FACE) Report:

Assistant Manager at Ice Rink Asphyxiated by an Oxygen-Deficient Atmosphere, Alaska, May 20, 1991.

National Inst. for Occupational Safety and Health, Morgantown, WV. Div. of Safety Research.

The case of a 24 year old male assistant manager for a shopping mall ice skating rink who was asphyxiated inside a compressor room while attempting to shut off a refrigerant gas leak was examined. The gas was chlorodifluoromethane-22 (75-45-6) (CFC-22). The employer was the owner of a 170 store indoor shopping mall which included a swimming pool and an ice skating rink. There was no safety policy or program in place. The refrigeration system had a long history of leaks. A large leak had been plugged in a makeshift fashion. A maintenance worker performing a routine check observed refrigerant oil oozing from under the doors to the compressor room. The victim, the maintenance supervisor, and a maintenance worker entered the compressor room through self closing doors. The victim was wearing a cartridge type respirator which was inadequate in an oxygen deficient atmosphere. A coworker called 911 after entering the compressor room and seeing two of the workers lying on the floor. The maintenance worker
[abstract truncated]

Occupational safety and health
Industrial safety
Safety measures
Environmental surveys
Toxic substances
Fatal Accident Circumstances and Epidemiology


75-45-6

NTIS/OTS0555876

EPA/OTS; Doc #88-920010607

1992

– INITIAL SUBMISSION:
CARDIAC
SENSITIZATION STUDY OF DICHLORODIFLUOROMETHANE, CHLORODIFLUOROMETHANE, 1,2-DICHLOROTETRAFLUOROETHANE, * IN DOGS WITH COVER LETTER DATED
10/15/92

HASKELL LABORATORY

E I DUPONT DE NEMOURS & CO


DICHLORODIFLUOROMETHANE, CHLORODIFLUOROMETHANE, 1,2-DICHLOR*
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION
NEUROTOXICITY
BIOCHEMISTRY
71-55-6

75-28-5

75-45-6

75-71-8


76-14-2

115-25-3

NTIS/OTS0546572

EPA/OTS; Doc #88-920010187



1992
– INITIAL SUBMISSION:
CARDIAC
SENSITIZATION TEST IN DOGS WITH COVER LETTER DATED
10-15-92

HASKELL LABS

DUPONT CHEM CO


FREON COMPOUNDS
HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
DOGS
INHALATION
71-55-6

75-28-5

75-45-6

75-71-8


76-14-2

76-15-3

115-25-3

NTIS/OTS0570941

EPA/OTS; Doc #88-920008896



1992
– INITIAL SUBMISSION: LETTER FROM DUPONT CHEM TO USEPA REGARDING
CARDIAC
SENSITIZATION STUDIES OF FREON COMPOUNDS IN DOGS WITH ATTACHMENTS AND COVER LETTER DATED
09-02-92

HASKELL LABORATORY

DUPONT CHEM


FREON COMPOUNDS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
PARENTERAL
INTRAPERITONEAL

INHALATION
51-43-4

71-55-6

75-28-5

75-45-6


75-71-8


76-14-2

76-15-3

115-25-3


NTIS/OTS0545701

EPA/OTS; Doc #88-920007447

1992

– INITIAL SUBMISSION: CHLORODIFLUOROMETHANE (CFC):
LONG-TERM INHALATION STUDY IN THE RAT
WITH COVER LETTER DATED
08-28-92


IMPERIAL CHEM INDUS LTD

ICI AMERS INC


CHLORODIFLUOROMETHANE
HEALTH EFFECTS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
MAMMALS
RATS
INHALATION


75-45-6



NTIS/OTS0546355

EPA/OTS; Doc #88-920008934

1992

– INITIAL SUBMISSION:
EMBRYONIC AND TERATOGENICITY STUDIES IN THE RAT
WITH INHALED CHLORODIFLUOROMETHANE(FC-22) WITH COVER LETTER DATED
09-02-92


HASKELL LABS

DUPONT CHEM CO


CHLORODIFLUOROMETHANE(FC-22)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION

75-45-6



NTIS/OTS05563292

EPA/OTS; Doc #88-920010933

1992

– INITIAL SUBMISSION: INHALATION TOXICITY STUDY OF FLUOR CHLOR REFRIGERANTS IN THE
GUINEA PIGS
WITH COVER LETTER DATED
10-18-92


E I DUPONT DE NEMOURS & CO

MONO-CHLORO-MONO-FLUORO-METHANE; DIFLUORO METHANE; MONO-CHL*
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
GUINEA PIGS
INHALATION
SUBCHRONIC TOXICITY
NEUROTOXICITY
BIOCHEMISTRY
75-10-5

75-45-6


593-70-4

NTIS/OTS0555047

EPA/OTS; Doc #88-920008229

1992

– INITIAL SUBMISSION: ACUTE INHALATION TOXICITY STUDY OF DETOXIFIED HIGH BOILERS (FREON 22 PYROLYSIS PRODUCTS) IN RATS WITH COVER LETTER DATED
09/01/92


TNO NUTRITION AND FOOD RESEARC

E I DUPONT DE NEMOURS & CO


“FREON” 22 PYROLYSIS
PRODUCTS/DETOXIFIED HIGH HIGH BOILERS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
RABBITS

75-45-6


NTIS/OTS0571901

EPA/OTS; Doc #88-920010755

1992

– INITIAL SUBMISSION:
TOXICITY TESTING SUMMARY FOR ALTERNATIVE FLUOROCARBONS
WITH COVER LETTER DATED
08-24-92


DUPONT CHEM


PHILLIPS PETROLEUM CO

FLUOROCARBONS
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
CHRONIC TOXICITY
CARCINOGENICITY
DOGS
PRIMARY EYE IRRITATION
RABBITS
DERMAL
PRIMARY DERMAL IRRITATION
GUINEA PIGS
PRIMARY DERMAL SENSITIZATION
75-10-5

75-37-6

75-43-4

75-45-6


75-68-3

75-88-7

306-83-2

593-70-4

811-97-2

2837-89-0


NTIS/OTS0522350

EPA/OTS; Doc #86-900000094


1990 –

A STUDY OF THE
RATE OF UPTAKE AND ELIMINATION
OF CHLORODIFLUOROMETHANE (HFA22) IN MAN BY THE INHALATION ROUTE WITH COVER LETTER DATED
02-07-90


ICI CENTRAL TOXICOL LAB

HFA22 (chlorodifluoromethane) was evaluated for pharmacokinetics in groups of 3 male humans exposed via inhalation to vapor concentrations of 92 or 518 ppm for 4 hours in an inhalation chamber. Blood and expired air samples were taken during exposure and for up to 26 hours after exposure. Urine samples were taken for up to 22 hours after exposure. The compound was absorbed very quickly, reaching plateaus of 0.25 and 1.36 ug/ml after approximately 4 and 3 hours of exposure for the low- and high-dose levels, respectively. End-tidal breath concentrations of the test compound during exposure were similar to the exposure concentration
s, indicating that only a small proportion of the available dose was absorbed. Elimination of the compound from blood was triphasic, with estimated half-lives of 0.005, 0.20, and 2.7 hours. The first phase probably corresponded to elimination from blood and rapidly perfused tissues, whereas the second and third phases of elimination probably corresponded to elimination from slowly perfused tissues and fat, respectively. The parent compound was detected in urine samples from all subjects; very little fluoride ion was detected in urine samples, indicating that the test compound was probably not metabolized to a significant extent.

Keywords:

ICI AMERICAS INC

CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
HUMANS
INHALATION


75-45-6


NTIS/OTS0522351

EPA/OTS; Doc #86-900000095

1990

– ARCTON 22: AN EVALUATION IN THE
MOUSE MICRONUCLEUS TEST
WITH COVER LETTER DATED
02-07-90



ICI CENTRAL TOXICOL LAB


Arcton 22 (chlorodifluoromethane) was evaluated for clastogenicity in C57BL/6JfCD-1/Alpk mice exposed to vapor concentrations of 0 (5 mice/sex), 50,000 (5 mice/sex) or 150,000 ppm (15 mice/sex) for 6 hours in a dynamic air-flow chamber. Mice were sacrificed and bone marrow was examined for micronucleated polychromatic erythrocytes at 24 hours after treatment with 50,000 ppm, and 24, 48, or 72 hours after treatment with 150,000 ppm. The frequency of micronucleated polychromatic erythrocytes did not increase in any of the treatment groups, indicating that Arcton 22 was not clastogenic in mice under the conditions of this assay.



Keywords:

ICI AMERICAS INC
ARCTON 22 (75-45-6)


HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS


MAMMALS
MICE
INHALATION

CAS Registry Numbers:

75-45-6


NTIS/OTS0526005

EPA/OTS; Doc #86-900000425

1990



ACUTE (4-HOUR) INHALATION TOXICITY STUDY WITH HHB UNTREATED AND HHB TREATED IN RATS WITH COVER LETTER

CIVO INSTITUTE TNO


E I DUPONT DENEMOURS & CO INC


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION

75-45-6


NTIS/OTS0520413

EPA/OTS; Doc #87-890000011

1989



EFFECT OF ACRTON 22 ON PREGNANT RATS: RELATIONSHIP TO
ANOPHTHALMIA AND MICROPHTHALMIA
WITH ATTACHMENTS AND COVER LETTER DATED
07-05-89


Teratogenicity was evaluated in 4 groups of 19 pregnant CD female rats receiving Arcton 22 via inhalation at concentration levels of 0, 100, 1,000 and 50,000 ppm for 6 hours per day on gestation days 6 through 15. There were no treatment-related effects in appearance, behavior, mortality, or pregnancy rate. At 50,000 ppm maternal weight gain was slightly lower than the control. There were no effects on body weight at 100 or 1,000 ppm. In all test groups litter size, post-implantation loss, litter wight, and mean fetal weight were similar to the control.
At 50,000, there was an increased incidence of anophthalmic fetuses.
Keywords:

ICI LTD
ARCTON 22 (75-45-6)
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
CAS Registry Numbers:

75-45-6


NTIS/OTS0520410

EPA/OTS; Doc #87-890000008

1989

– INHALATION EXPOSURE WITH COVER LETTER DATED
07-05-89


CENTRAL TOXICOL LAB


MPERIAL CHEM INDUS LTD

ARCTON 22
(75-45-6)


HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION

75-45-6



NTIS/OTS0520989

EPA/OTS; Doc #86-890000874S

1989


EMBRYOTOXIC AND TERATOGENIC STUDIES IN RAT
WITH INHALED CHLORODIFLUOROMETHANE (FC-22) WITH COVER SHEET DATED
06-12-89 (SANITIZED)


HASKELL LABORATORIES

E I DUPONT DE NEMOURS & CO


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY

75-45-6



NTIS/OTS0520990

EPA/OTS; Doc #86-890000875S

1989


EMBRYOTOXIC AND TERATOGENIC STUDIES IN RATS
WITH INHALED CHLORODIFLUOROMETHANE (FC-22) WITH ATTACHMENTS AND COVER SHEET DATED
06-12-89 (SANITIZED)


HASKELL LABORATORIES

E I DUPONT DE NEMOURS & CO


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY

75-45-6

NTIS/OTS0520412

EPA/OTS; Doc #87-890000010

1989


EFFECT OF ARCTON 22 ON PREGNANCY OF THE NEW ZEALAND WHITE RABBIT WITH ATTACHMENTS AND COVER LETTER DATED
07-05-89


Teratogenicity was evaluated in 4 groups of 14 to 16 pregnant New Zealand white female rabbits receiving Arcton 22 (chlorodifluoromethane) via inhalation at concentration levels of 0, 100, 1,000 and 50,000 ppm for 6 hours per day on gestation days 6 through 18. There were no signs of treatment-related effects on mortality or pregnancy rate. At the highest concentration level there was slight weight loss during the first 4 days of exposure, but weight gains were comparable to controls. Litter values (determined by litter size, implantation loss, litter and mean fetal weights) were similar to the control at all exposure levels.
There were no signs of treatment-related embryonic or fetal malformations noted. Parameters such as the number of corpora lutea, implantations per dam, resorption rates, fetal weights and or sex distribution were not reported

Keywords:

ICI LTD
ARCTON 22 (75-45-6)


HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RABBITS
INHALATION

CAS Registry Numbers:

75-45-6


NTIS/OTS0516686

EPA/OTS; Doc #86-890000160

1989

– DATENBLATT ALTSTOFFE
TOXICOLOGICAL PROFILES FOR 3 CHEMICALS
WITH COVER LETTER DATED
03-17-89



HOECHST CELANESE CORP

4-NITROPHENOL (100-02-7)
HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
DOGS
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
FISH-FRESHWATER
ALGAE
INVERTEBRATES
BACTERIA
GENOTOXICITY
GENE MUTATIONS
IN VITRO
ORAL
DERMAL
PRIMARY DERMAL IRRITATION
RABBITS
PRIMARY EYE IRRITATION

75-45-6


76-13-1

100-02-7



NTIS/OTS0520835

EPA/OTS; Doc #86-890001332

1989

– LETTER FROM
ICI AMERICAS
INCORPORATED TO THE USEPA CONCERNING CHLORODIFLUOROMETHANE
LONG-TERRM INHALATION STUDY
WITH COVER SHEETS AND LETTER DATED
07-24-89


ICI AMERICAS INC


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
INHALATION
MICE

75-45-6


NTIS/OTS0520838

EPA/OTS; Doc #86-890001335

1989


TOXICITY REVIEW
OF FREON 22 – CHLORODIFLUOROMETHANE WITH COVER SHEETS AND LETTER DATED
07-24-89


HASKELL CORPORATION

E I DUPONT DE NEMOURS & CO


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
SUBCHRONIC TOXICITY
GUINEA PIGS
DOGS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
HAMSTERS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
75-45-6


NTIS/OTS0520993

EPA/OTS; Doc #86-890000878

1989

– CHINESE HAMSTER OVARY CELL ASSAY FOR MUTAGENICITY WITH ATTACHMENTS AND COVER SHEET DATED
06-12-89

HASKELL LABORATORIES

The ability of chlorodifluoromethane to cause mutation at the gene locus coding for hypoxanthine-guanine phosphoribosyl transferase in Chinese hamster ovary cells (CHO/HGPRT Assay) was evaluated in the presence and absence of metabolic activation from Aroclor-induced rat liver S9 fraction. Results of preliminary toxicity tests of non-activated cultures treated with concentrations of 0, 20, 31, 33, 58, 60, 73, 75, 83, and 92% chlorodifluoromethane produced plating efficiences ranging from 115.9 to 93.2% relative to the nitrogen gas control. Assays of activated cultures at concentrations of 0, 32, 36, 60, 70, 76, 78, 81, and 82% produced cloning efficiencies ranging from 109.9 to 78.3% relative to the nitrogen gas control. Neither the activated nor non-activated cultures exhibited a significant increase in mutant frequency relative to the negative control. Keywords:

E I DUPONT DE NEMOURS & CO

CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
MAMMALS
HAMSTERS
IN VITRO75-45-6


NTIS/OTS0520411

EPA/OTS; Doc #87-890000009

1989

– ARCTON 22 (CHLORODIFLUOROMETHANE) – RELATIONSHIP BETWEEN
BLOOD LEVELS AND INHALED CONCENTRATIONS
IN ANAESTHETISED, ARTIFICALLY-VENTILATED RATS WITH COVER LETTER DATED
07-05-89


CENTRAL TOXICOL LAB


IMPERIAL CHEM INDUS LTD
ARCTON 22 (75-45-6)


HEALTH EFFECTS
BIOCHEMISTRY
MAMMALS
RATS
INHALATION

75-45-6


NTIS/OTS0520992

EPA/OTS; Doc #86-890000877

1989

– MUTAGENIC ACTIVITY OF CHLORODIFLUOROMETHANE IN THE SALMONELLA/MICROSOME ASSAY WITH ATTACHMENTS AND COVER SHEET DATED
06-12-89

HASKELL LABORATORIES

The mutagenicity of chlorodifluoromethane was evaluated in Salmonella tester strains TA98, TA100, TA1535, and TA1537 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, the material was tested for mutagenicity at concentrations of 0, 15, 25, and 40% (of the atmosphere) using the dessicator method. The material caused a reproducible positive response in tester strain TA1535, both in the presence and absence of S9 activation. Chlorodifluoromethane did not cause a reproducible positive response in tester strains TA98, TA100, and TA1537, either in the presence or absence of added metabolic activation.

Keywords:

E I DUPONT DE NEMOURS & CO

CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO


75-45-6

NTIS/OTS0520991

EPA/OTS; Doc #86-890000876

1989

– IN VITRO MICROBIAL MUTAGENICITY STUDIES OF CHLORODIFLUOROMETHANEWITH ATTACHMENTS AND COVER SHEET DATED
612-89


HASKELL LABORATORIES



The mutagenicity of chlorodifluoromethane was evaluated in Salmonella tester strains TA98, TA100, TA1535, TA1537, and TA1538 (Ames Test), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. Based on the results of preliminary bacterial toxicity testing, the material was tested for mutagenicity at concentrations of 0, 20, and 40% (of the atmosphere) using the dessicator method. Chlorodifluoromethane did not cause a reproducible positive response in any of the bacterial tester strains, either in the presence or absence of added metabolic activation.


Keywords:

E I DUPONT DE NEMOURS & CO

CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO

75-45-6

NTIS/OTS0520424

EPA/OTS; Doc #86-890000318

1989

– A TABLE OF ACUTE ORAL AND
DERMAL
LD50’S AND INHALATION LD50’S FOR FLUOROCARBON-11, 12, 22, 113, 114, 115, AND 152A WITH ATTACHMENTS AND COVER LETTER DATED
06-09-89


HASKELL LABORATORIES

E I DUPONT DE NEMOURS & CO


FLUOROCARBON 152A (75-37-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL
75-37-6

75-45-6

75-69-4

75-71-8


76-13-1

76-14-2

76-15-3

NTIS/OTS0520425

EPA/OTS; Doc #86-890000319

1989

– A TABLE OF ACUTE ORAL, AND
DERMA
L LD50’S AND INHALATION LD50’S FOR FC-11, 12, 22, 113, 114, 115, AND 152A WITH ATTACHMENTS AND COVER LETTER DATED
06-09-89

HASKELL LABORATORIES


E I DUPONT DE NEMOURS & CO


FLUOROCARBON 152A (75-68-3)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL
75-37-6

75-45-6

75-69-4

75-71-8


76-13-1

76-14-2

76-15-3

NTIS/OTS0520218

EPA/OTS; Doc #86-890001075

1989

– LETTER REGARDING THE REQUESTED INFORMATION ON ATMOSPHERIC LIFETIMES AND
OZONE DEPLETION POTENTIALS
CALCULATED USING 1-D MODELS WITH ATTACHMENTS AND COVER LETTER
07-10-89


E I DUPONT DE NEMOURS & CO


CHLOROFLUOROCARBONS
(75-45-6)

ENVIRONMENTAL FATE

56-23-5

75-45-6

75-69-4

75-71-8


76-13-1

76-14-2

76-15-3

306-83-2

431-06-1

2837-89-0

25323-89-1

NTIS/OTS0520416

EPA/OTS; Doc #87-890000014

1989


FISH TOXICITY
OF FRIGENS WITH COVER LETTER DATED
07-28-89


HOECHST CELANESE CORP


FRIGEN 113 (76-13-1)
ENVIRONMENTAL EFFECTS
ACUTE TOXICITY
FISH-FRESHWATER

75-45-6


75-69-4

75-71-8


76-13-1

76-14-2

NTIS/OTS0520994

EPA/OTS; Doc #86-890000879

1989


CARDIAC
SENSITIZATION WITH ATTACHMENT AND COVER SHEET DATED
06-12-89

HASKELL LABORATORIES

E I DUPONT DE NEMOURS & CO


CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION
71-55-6

75-28-5

75-45-6


75-71-8


76-14-2

76-15-3

115-25-3



NTIS/OTS0000695

EPA/OTS; Doc #FYI-OTS-0689-0695

1989

– ARCTON 134A DOMINANT LETHAL STUDY IN THE MOUSE, EXCRETION, TISSUE DISTRIBUTION AND METABOLISM IN RAT, TERATOGENICITY, CYTOGENTIC, AND SUB-ACUTE STUDIES IN RATS WITH LETTER
06-21-89


IMPERIAL CHEM INUS LTD

ICI PRODUCTS LTD


ARCTON 134A
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
ORAL
GAVAGE
CELL TRANSFORMATION
HAMSTERS
CHROMOSOMAL EFFECTS
INHALATION
PHARMACO KINETICS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
SUBCHRONIC TOXICITY
MICE

75-45-6


75-88-7

420-46-2

593-70-4

811-97-2



NTIS/OTS0520837


EPA/OTS; Doc #86-890001334

1989

– LETTER FROM E I DUPONT DE NEMOURS & COMPANY CONCERNING
TOXICITY REVIEW OF FLUOROCARBON 22
WITH COVER SHEETS AND LETTER DATED
07-24-89



E I DUPONT DE NEMOURS & CO

CHLORODIFLUOROMETHANE
(75-45-6)

HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO
CHRONIC TOXICITY
CARCINOGENICITY
MAMMALS
RATS
INHALATION
MICE

75-45-6

NTIS/OTS0520423

EPA/OTS; Doc #86-890000317

1989

– HEALTH & SAFETY STUDIES ON ISOTRON 142B, ISOTRON 22, FLUOROCARBON 152A AND ISOTRON 113 WITH ATTACHED APPENDICES AND COVER LETTER DATED
06-09-89


CENTRAL TOXICOL LAB

PENWALT CORP


ISOTRON 142B (75-68-3)
HEALTH EFFECTS
GENOTOXICITY
CHROMOSOMAL EFFECTS
MAMMALS
MICE
INHALATION
RATS
CHRONIC TOXICITY
COMBINED CHRONIC TOXICITY/CARCINOGENICITY
PHARMACO KINETICS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
RABBITS
SUBCHRONIC TOXICITY
GUINEA PIGS
IN VITRO

75-45-6


NTIS/OTS0520424

EPA/OTS; Doc #86-890000318

1989

– A TABLE OF
ACUTE ORAL AND DERMAL LD50’S AND INHALATION LD50’S
FOR FLUOROCARBON-11, 12, 22, 113, 114, 115, AND 152A WITH ATTACHMENTS AND COVER LETTER DATED
06-09-89


HASKELL LABORATORIES

E I DUPONT DE NEMOURS & CO


FLUOROCARBON 152A (75-37-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL
75-37-6

75-45-6

75-69-4

75-71-8

76-13-1

76-14-2

76-15-3



NTIS/OTS0520425

EPA/OTS; Doc #86-890000319

1989

– A TABLE OF
ACUTE ORAL, AND DERMAL LD50’S AND INHALATION LD50’S
FOR FC-11, 12, 22, 113, 114, 115, AND 152A WITH ATTACHMENTS AND COVER LETTER DATED
06-09-89


HASKELL LABORATORIES


E I DUPONT DE NEMOURS & CO

FLUOROCARBON 152A (75-68-3)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
INHALATION
PHARMACO KINETICS
SUBCHRONIC TOXICITY
ORAL
RABBITS
DERMAL
75-37-6

75-45-6


75-69-4

75-71-8

76-13-1

76-14-2

76-15-3

NTIS/OTS0520985

EPA/OTS; Doc #86-890000870

1989


CARDIAC
SENSITIZATION WITH ATTACHMENTS AND COVER SHEET DATED
06-12-89


HASKELL LABORATORIES


E I DUPONT DE NEMOURS & CO
CHLORODIFLUOROMETHANE (75-45-6)


HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION
74-98-6

75-01-4

75-37-6

75-45-6


75-68-3

76-15-3

115-10-6

127-18-4

NTIS/OTS0520943

EPA/OTS; Doc #86-890000827

1989


CARDIAC
SENSITIZATION WITH ATTACHMENT AND COVER SHEET DATED
06-12-89


HASKELL LABORATORIES


E I DUPONT DE NEMOURS & CO

1,1-DIFLUOROETHANE (75-37-6)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION
74-98-6

75-01-4

75-37-6

75-45-6


75-68-3

76-15-3

115-10-6

127-18-4


NTIS/OTS0520982

EPA/OTS; Doc #86-890000867

1989


CARDIAC
SENSITIZATION WITH ATTACHMENTS AND COVER SHEET DATED
06-12-89


HASKELL LABORATORIES


E I DUPONT DE NEMOURS & CO

1-CHLORO-1,1-DIFLUOROETHANE (75-68-3)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
DOGS
INHALATION
74-98-6

75-01-4

75-37-6

75-45-6


75-68-3

76-15-3

115-10-6

127-18-4


NTIS/OTS0516797

EPA/OTS; Doc #86-890000263

1989

– HEALTH AND SAFETY STUDIES FOR 19 CHEMICALS WITH COVER LETTER DATED
06-02-89


HUNTINGDON RES CTR


UNION CARBIDE CORP

DIMETHYLFORMAMIDE (68-12-2)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
RATS
ORAL
GAVAGE
RABBITS
DERMAL
INHALATION
ENVIRONMENTAL FATE
BIODEGRADATION
PRIMARY DERMAL IRRITATION
GUINEA PIGS
PRIMARY DERMAL SENSITIZATION
PRIMARY EYE IRRITATION
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MICE
ENVIRONMENTAL EFFECTS
FISH-FRESHWATER
INVERTEBRATES
SUBCHRONIC TOXICITY
BIOCHEMISTRY
DOGS
PARENTERAL
INTRAVENOUS
INTRAPERITONEAL
PHARMACO KINETICS
HUMANS
GENOTOXICITY
GENE MUTATIONS
HAMSTERS
IN VITRO
DNA EFFECTS
CHROMOSOMAL EFFECTS
MICROBIAL FUNCTION TESTS
BACTERIA
CHRONIC TOXICITY
68-12-2

75-45-6


76-13-1

80-62-6

95-14-7

96-45-7

102-71-6

107-98-2

108-88-3

111-42-2

111-76-2

111-77-3

111-90-0

124-16-3

140-88-5

141-43-5

25498-49-1

29385-43-1

34590-94-8



NTIS/OTS0521033

EPA/OTS; Doc #86-890001417

1989

– HEALTH HAZARD EVALUATION REPORT CONCERNING
REFRIGERATION WORKERS IN SALT LAKE CITY
WITH COVER LETTER DATED
07-28-89


RACON INC
CHLOROPENTAFLUOROETHANE (76-15-3)
HEALTH EFFECTS
EPIDEMIOLOGY

75-45-6


75-69-4


NTIS/OTS0520616

EPA/OTS; Doc #86-890000577S

1989


SUBACUTE INHALATION
TOXICITY STUDY IN ALBINO RATS WITH ATTACHMENTS AND COVER LETTER DATED
06-12-89 (SANITIZED)



CONFIDENTIAL

CHLORODIFLUOROMETHANE (75-45-6)

HEALTH EFFECTS
SUBCHRONIC TOXICITY
MAMMALS
RATS
INHALATION
75-43-4


NTIS/OTS0000602-1

EPA/OTS; Doc #FYI-OTS-0988-0602

1988

– SIMULATED
CONSUMER EXPOSURE TO PROPELLANT HCFC 22 (CHLORODIFLUOROMETHANE)

IN AEROSOL PERSONAL PRODUCTS WITH COVER LETTER DATED
09-13-88

LEVER BROS CO


CHLORODIFLUOROMETHANE
HEALTH EFFECTS
INDUSTRIAL HYGIENE

75-45-6


NTIS/OTS0000602-2

EPA/OTS; Doc #FYI-OTS-0688-0602D

1988

– ARCTON 22:
PHARMACOKINETICS IN THE PREGNANT FEMALE RAT
FOLLOWING INHALATION EXPOSURE &
MODEL PREDICTIONS OF BLOOD CONCENTRATION & BODY BURDEN OF FC22 IN HUMANS & RATS
WITH LETTER
IMPERIAL CHEMICAL INDUS


ARCTON 22

HEALTH EFFECTS
PHARMACO KINETICS
MAMMALS
RATS
INHALATION

75-45-6


NTIS/OTS0000111-0

EPA/OTS; Doc #FYI-OTS-0481-0111

1985

– CHLOROFLUOROCARBON 22(CFC 22-CHLORODIFLUROMETHANE)

1C1 LTD CTR TOXICOL LAB



ICI AMERS INC

METHANE, CHLORODIFLUORO-
HEALTH EFFECTS
CHRONIC TOXICITY
CARCINOGENICITY

MAMMALS
RATS
INHALATION
MICE

75-45-6


NTIS/OTS0205948

EPA/OTS; Doc #878211462

1982

– MUTAGENIC ASSAY OF T-1716AC AEROSOL WITH AND WITHOUT METABOLIC ACTIVATION WITH COVER LETTER


INDUS BIO TEST LABS INC

The mutagenicity of 1,1,1-trichloroethane (TCE) was evaluated in Salmonella tester strain TA100 (Ames Test, desiccator assay variation), both in the presence and absence of added metabolic activation by Aroclor-induced rat liver S9 fraction. TCE was tested for mutagenicity at dose levels of 0.4, 1.90 and 8.92 gm/desiccator. No rationale for selection of dose levels used was reported. TCE caused a positive response in strain TA100 with metabolic activation at 1.90 ml/desiccator. The mutagenicity of T-1716AC (60% TCE, 30% monochlorodifluoromethane, and <2% 1,4-dioxane) was evaluated in the same strain under the same conditions as abov e. Although the dose levels were not reported, the authors did state that the mixture was discharged for time periods of 0.5, 1.0 and 5.0 seconds. T-1716AC did not cause a reproducible positive response in TA100 at any of the exposure periods.

Keywords:

MINNESOTA MINING & MFG CO

1,1,1-TRICHLOROETHANE (71-55-6)
HEALTH EFFECTS
GENOTOXICITY
GENE MUTATIONS
BACTERIA
IN VITRO

CAS Registry Numbers:

71-55-6

75-45-6


123-91-1

NTIS/OTS0527479

EPA/OTS; Doc #40-8023083

1980

– ACQUISITION AND CHEMICAL
ANALYSIS OF MOTHER’S MILK
FOR SELECTED TOXIC SUBSTANCES (DECEMBER
1980)



RESEARCH TRIANGLE INST


Samples of mother’s milk were collected from persons in 5 cities and analyzed by gas chromatography and spectrophotometry for volatile and semivolatile organics. In the volatile fraction, 26 halogenated hydrocarbons, 17 aldehydes, 20 ketones, 11 alcohols, 2 acids, 3 ethers, 1 epoxide, 14 furans, 26 other oxygenated compounds, 4 sulfur-containing compounds, 7 nitrogen-containing compounds, 13 alkanes, 12 alkenes, 7 alkynes, 11 cyclic hydrocarbons, and 15 aromatics were found, including major peaks for hexanol, limonene, dichlorobenzene, and some esters. Semivolatile compounds of interest that were identified in the samples were polychlorinated biphenyls and DDE. Polychlorinated naphthalenes, polybrominated biphenyls, chlorinated phenols, and other compounds were specifically sought but not detected (limit of detection was about 20-100 ng/mL mild).
The prevalent halogenated compounds in ambient air and water near 2 New Jersey and 3 Louisiana cities were identified and quantified. Potential emissions from chemical industries in 3 Louisiana cities were listed and quantified.

Keywords:

U S EPA
CYCLOHEXANE
HEALTH EFFECTS
EPIDEMIOLOGY
ENVIRONMENTAL FATE
MONITORING
PRODUCTION AND PROCESS

CAS Registry Numbers:

75-45-6


[too many to list]



NTIS/OTS0000002-0

EPA/OTS; Doc #FYI-OTS-0878-0002

1978


WEAK TERATOGENIC EFFECT IN RATS
EXPOSED TO FC22 WITH ATTACHED LETTER TO OTS & CUSTOMER ADVISORY LETTER


HASKELL LABS

E I DUPONT DENEMOURS & CO INC


METHANE, CHLORODIFLUORO
HEALTH EFFECTS
REPRODUCTION/FERTILITY EFFECTS
TERATOGENICITY
MAMMALS
RATS
INHALATION

75-45-6



Table 2.

Studies available from The National Technical Information Service(NTIS)





Order from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at [email protected] NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.

These studies were cited at Toxline at Toxnet on Dec 10, 2004.

Order No. Title/Date Keywords / CAS Nos. / Abstract

NTIS/OTS0529142

EPA/OTS; Doc #110-881013

2000

– SUPPORT DOCUMENT FOR THE SARA SECTION 110 “SECOND 100” LIST (DRAFT)

Keywords:

U S EPA
CHLORIDE
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

75-45-6

[too many to list]


NTIS/OTS0523799


EPA/OTS; Doc #40-7834109

2000

– FLUOROCARBONS – AN INDUSTRIAL HYGIENE SURVEY OF WORKERS EXPOSURE IN FOUR FACILITIES

Keywords:

NIOSH

FLUOROALKENES
HEALTH EFFECTS
INDUSTRIAL HYGIENE

CAS Registry Numbers:

56-23-5

64-17-5

67-56-1

67-63-0

71-55-6

75-09-2

75-45-6

75-46-7

75-63-8
75-68-3

75-69-4

75-71-

8


75-72-9

76-13-1

76-14-2

76-15-3

76-16-4
79-01-6

95-47-6

106-42-3

108-38-3

127-18-4

353-36-6

624-72-6

7664-39-3


NTIS/OTS0520133

EPA/OTS; Doc #86-890000989S

2000

– LETTER FROM E I DUPONT DE NEMOURS & COMPANY REGARDING INFORMATION ON THE LEAKS THAT WERE FOUND IN THE REFRIGERANT CHARGING SYSTEMS AND THE BULK HANDLING FACILITIES
(SANITIZED)

Keywords:

E I DUPONT DE NEMOURS & CO FREON (75-45-6)

HEALTH EFFECTS
INDUSTRIAL HYGIENE

CAS Registry Numbers:

75-45-6


NTIS/OTS0523799

EPA/OTS; Doc #40-7834109

2000

– FLUOROCARBONS – AN INDUSTRIAL HYGIENE
SURVEY OF WORKERS EXPOSURE IN FOUR FACILITIES


Keywords:

NIOSH
FLUOROALKENES
HEALTH EFFECTS
INDUSTRIAL HYGIENE

CAS Registry Numbers:

56-23-5

64-17-5

67-56-1

67-63-0

71-55-6

75-09-2

75-45-6

75-46-7


75-63-8

75-68-3

75-69-4

75-71-8
75-72-9

76-13-1

76-14-2

76-15-3

76-16-4

79-01-6

95-47-6

106-42-3

108-38-3

127-18-4

353-36-6

624-72-6

7664-39-3


NTIS/OTS0558956

EPA/OTS; Doc #86970000746

1997


FINAL REPORT ON MODELING STUDIES
TO ASSESS THE ENVIRONMENTAL EFFECTS OF
ALTERNATIVE CFCS
, WITH COVER LETTER DATED
3/17/1997


ATMOS & ENVIRON RESEARCH INC

Keywords:

AFEAS
METHANE, DICHLORO-FLUORO- (75-43-4); *
ENVIRONMENTAL FATE
MONITORING
TRANSPORT PROCESSES
PHOTOLYSIS
HYDROLYSIS

CAS Registry Numbers:

56-23-5

71-55-6

75-37-6

75-43-4

75-45-6


75-68-3

75-69-4

75-71-8

76-05-1
76-13-1

76-14-2

76-15-3

306-83-2

354-33-6

811-97-2

1717-00-6

2837-89-0

10028-15-6


NTIS/OTS0557597

EPA/OTS; Doc #86950000084

1995

– MODEL ASSESSMENT OF THE ODP’S OF HALOCARBONS: THE
OZONE-DEPLETION EFFIENCIES
OF THE
CF3 RADICALS, FCO RADICALS AND FLUORINE RADICALS, WITH COVER LETTER DATED
01/31/95

ATMOSPHERIC ENVIR RESEARCH INC

Keywords:

AFEAS
ETHANE, 1-CHLORO-1,1-DIFLUORO- (75-68-3)
ENVIRONMENTAL FATE
PHOTOLYSIS

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6


75-68-3

75-88-7

306-83-2

354-33-6

811-97-2
1649-08-7

1717-00-6

2837-89-0

10028-15-6

10102-43-9

10102-44-0

21811-29-0

118986-32-6


NTIS/OTS0572576

EPA/OTS; Doc #86950000270

1995

– MODELING STUDIES TO ASSESS THE
ENVIRONMENTAL EFFECTS OF ALTERNATIVE CFCS
WITH COVER LETTER DATED
08/15/95


ATMOSPHERIC & ENVRN RESEARCH

Keywords:

AFEAS
HCFC-22 (CAS# 75-45-6)

ENVIRONMENTAL FATE
BIODEGRADATION

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6

75-68-3

75-88-7

306-83-2

354-33-6

811-97-2

1649-08-7

1717-00-6


NTIS/OTS0572575

EPA/OTS; Doc #86950000269

1995

– AN INVESTIGATION OF THE HCFC-22 (CHCLF2) CONTENT OF THE
CAPE GRIM AIR ARCHIVE TO DETERMINE THE ATMOSPHERIC LIFETIME HCFC-22
WITH COVER LETTER DATED
08/15/95


Keywords:

AFEAS
HCFC-22 (CAS# 75-45-6)
ENVIRONMENTAL FATE
BIODEGRADATION

CAS Registry Numbers:

75-45-6

NTIS/OTS0556814

EPA/OTS; Doc #86940000219

1994

– KINETICS AND MECHANISMS FOR THE REACTIONS OF HALOGENATED ORGANIC COMPOUNDS IN THE
TROPOSPHERE
– STEP-HALOCSIDE/AFEAS WORKSHOP, WITH COVER LETTER DATED
03-24-94


UNIV COLLEGE DUBLIN

Keywords:

AFEAS
ETHANE, 1,1,1,2-TETRAFLUORO- (811-97-2)
ENVIRONMENTAL FATE
PHYSICAL/CHEMICAL PROPERTIES
PHOTOLYSIS
TRANSPORT PROCESSES
HYDROLYSIS
HENRY’S LAW CONSTANT

CAS Registry Numbers:

75-45-6



[Note: too many to list]


NTIS/OTS0557534

EPA/OTS; Doc #86950000021

1994


FINAL REPORT, A GLOBAL THREE-DIMENSIONAL STUDY OF THE FATE OF HCFC’S AND HFC-134A IN THE TROPOSPHERE,
WITH COVER LETTER DATED 10/28/94

MAX-PLANCK-INST FOR CHEM


Keywords:

AFEAS
METHANE, CHLORO-DIFLUORO- (75-45-6)
ENVIRONMENTAL FATE
TRANSPORT PROCESSES
PHOTOLYSIS
HYDROLYSIS

CAS Registry Numbers:

75-45-6


75-68-3

306-83-2

811-97-2

1717-00-6

2837-89-0



NTIS/OTS0557452

EPA/OTS; Doc #86940001156

1994

– STATISTICAL ANALYSIS OF
ATMOSPHERIC TOTAL OZONE DATA
, UMKEHR OZONE PROFILE DATA, OZONESONDE PROFILE DATA AND STRATOSPHERIC TEMPERATURE DATA WITH COVER LETTER DATED
06/27/94



UNIV WISCONSIN

Keywords:

AFEAS
METHANE, DICHLORO-FLUORO (75-43-4)
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6


75-68-3

75-88-7

306-83-2

354-33-6

811-97-2

1649-08-7

1717-00-6

2837-89-0

10028-15-6


NTIS/OTS0538237

EPA/OTS; Doc #86-930000413

1993

– TOXICOLOGICAL EVALUATION OF SAMPLING DATA FOR
LITTLE ROCKY CREEK, GREENVILLE, SOUTH CAROLINA
WITH COVER LETTER DATED
05-07-93


HAZ SUBS & WASTE MANAG RES INC

Keywords:

ETHENE, TETRACHLORO (127-18-4)
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

56-23-5

67-66-3

71-55-6

75-01-4

75-09-2

75-27-4

75-34-3

75-35-4

75-45-6


78-87-5
79-01-6

79-34-5

100-41-4

106-46-7

107-06-2

108-88-3

127-18-4

540-59-0

541-73-1

10061-01-5


NTIS/OTS0538266

EPA/OTS; Doc #86-930000442

1993


OXIDATION OF HALOACETATES (FINAL REPORT)
WITH COVER LETTER DATED
08-26-93



NST

Keywords:

AFEAS
METHANE, DICHLORO-FLUORO- (75-43-4)
ENVIRONMENTAL FATE

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6



75-68-3

75-88-7

306-83-2

354-33-6

811-97-2

1649-08-7

1717-00-6

63938-10-3


NTIS/OTS0538263

EPA/OTS; Doc #86-930000439

1993

– MEASUREMENTS OF HCFC-22 AND OTHER ALTERNATIVE FLUOROCARBONS IN THE
ARCTIC STRATOSPHERE
WITH COVER LETTER DATED
08-26-93


UNIV EAST ANGLIA

Keywords:

AFEAS
METHANE, DICHLORO-FLUORO- (75-43-4)
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6


75-68-3

75-88-7

306-83-2

354-33-6

811-97-2

1649-08-7

1717-00-6

63938-10-3



NTIS/OTS0537654

EPA/OTS; Doc #86-930000211

1993

– FT-IR STUDY OF THE
TROPOSPHERIC REACTIONS
OF CF3O RADICALS WITH NO AND NO2 WITH COVER LETTER


YORK UNIVERSITY

Keywords:

AFEAS
DICHLOROFLUOROMETHANE (75-43-4)
ENVIRONMENTAL FATE
PHOTOLYSIS

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6


75-68-3

75-88-7

306-83-2

354-33-6

811-97-2

1649-08-7

2837-89-0


NTIS/OTS0535617

EPA/OTS; Doc #86-920000827

1992

– LETTER SUBMITTING ONE ENCLOSED STUDY ON THE REACTIONS OF CHLOROFLUOROCARBONS IN THE
TROPOSPHERE
AND ONE ENCLOSED STUDY ON
GLOBAL WARMING

Keywords:

AFEAS
DICHLOROFLUOROMETHANE (75-43-4)
ENVIRONMENTAL FATE

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6


75-68-3

75-88-7

306-83-2

354-33-6

811-97-2

1649-08-7

1717-00-6

63938-10-3


NTIS/OTS0535634

EPA/OTS; Doc #86-920000892S

1992

– LETTER SUBMITTING ONE ENCLOSED
ENVIRONMENTAL TESTING STUDY
AND ONE ENCLOSED
CHEMICAL ENGINEERING TESTING STUDY
ON THREE HYDROFLUOROCARBONS & ONE HYDROCHLOROFLUOROCARBON
(SANITIZED)

Keywords:

DUPONT CHEMS

CHLORODIFLUOROMETHANE (75-45-6)

ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


354-33-6

811-97-2

2837-89-0


NTIS/OTS0535635


EPA/OTS; Doc #86-920000893S

1992

– LETTER SUBMITTING ONE ENCLOSED
ENVIRONMENTAL TESTING STUDY
AND ONE ENCLOSED
CHEMICAL ENGINEERING TESTING STUDY
ON THREE HYDROFLUOROCARBONS & ONE HYDROCHLOROFLUOROCARBON
(SANITIZED)

Keywords:

DUPONT CHEMS

CHLORODIFLUOROMETHANE (75-45-6)

ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


354-33-6

811-97-2

2837-89-0


NTIS/OTS0529948


EPA/OTS; Doc #86-910000929

1991

– AB 2588 HEALTH RISK ASSESSMENT FOR
3M PHARMACEUTICALS FACILITY IN NORTHRIDGE, CALIFORNIA
(VOLUME 1) WITH ATTACHMENTS, COVER SHEETS AND LETTER DATED
07-10-91


CHEM RISK DIVISION

Keywords:

3M CO

TOLUENE (108-88-3)
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

67-56-1

67-66-3

75-09-2

75-45-6

75-69-4

75-71-8


76-14-2

76-15-3

1310-73-2


NTIS/OTS0529948

EPA/OTS; Doc #86-910000929

1991

– AB 2588 HEALTH RISK ASSESSMENT FOR
3M PHARMACEUTICALS FACILITY IN NORTHRIDGE, CALIFORNIA
(VOLUME 1) WITH ATTACHMENTS, COVER SHEETS AND LETTER DATED
07-10-91



CHEM RISK DIVISION


Keywords:

3M CO

TOLUENE (108-88-3)
ENVIRONMENTAL FATE
MONITORING
CAS Registry Numbers:

67-56-1

67-66-3

75-09-2

75-45-6


75-69-4

75-71-8

76-14-2

76-15-3

1310-73-2

NTIS/OTS0520193

EPA/OTS; Doc #86-890001050



1989



MEMORANDUM REGARDING FLUOROCARBON
OZONE DEPLETION POTENTIALS
WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

FLUOROCARBON OZONE
ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-69-4

75-71-8


76-13-1

76-14-2

76-15-3

NTIS/OTS0520210

EPA/OTS; Doc #86-890001067



1989 –
INTEROFFICE MEMORANDUM REGARDING
CORRECTED GREENHOUSE POTENTIAL CALCULATIONS
WITH ATTACHMENTS AND COVER LETTER
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

CHLOROFLUOROCARBONS (75-45-6)
ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-71-8


431-06-1

2837-89-0

NTIS/OTS0520211

EPA/OTS; Doc #86-890001068



1989 –

INTEROFFICE MEMORANDUM REGARDING
CORRECTED GREENHOUSE POTENTIAL ESTIMATES
WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89


Keywords:

E I DUPONT DE NEMOURS & CO

CHLOROFLUOROCABRONS (75-45-6)
ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-71-8


431-06-1

2837-89-0

NTIS/OTS0520212

EPA/OTS; Doc #86-890001069



1989 –

INTEROFFICE MEMORANDUM REGARDING
GREENHOUSE POTENTIAL CALCULATION RESULTS
WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89


Keywords:

E I DUPONT DE NEMOURS & CO

CHLOROFLUOROCARBONS
(75-45-6)

ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-71-8

431-06-1


2837-89-0

NTIS/OTS0520213

EPA/OTS; Doc #86-890001070



1989

MEMORANDUM REGARDING
GREENHOUSE POTENTIALS
OF SOME ADDITIONAL ALTERNATIVE CHLOROFLUOROCARBONS (CFCS) WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89


Keywords:

E I DUPONT DE NEMOUS & CO

CHLOROFLUOROCARBONS
(75-45-6)

ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-68-3

75-71-8


306-83-2

2837-89-0

NTIS/OTS0520214

EPA/OTS; Doc #86-890001071



1989



INTEROFFICE MEMORANDUM REGARDING
GREENHOUSE POTENTIALS
OF SOME ADDITIONAL ALTERNATIVE CHLOROFLUOROCARBONS (CFCS) WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

CHLOROFLUOROCARBONS
(75-45-6)

ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-71-8


306-83-2

431-06-1

2837-89-0


NTIS/OTS0520222

EPA/OTS; Doc #86-890001079



1989



CALCULATED
OZONE DEPLETION POTENTIALS, DUPONT ONE-DIMENSIONAL CHEMISTRY-TRANSPORT MODEL WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

CHLOROFLUOROCARBONS
(75-45-6)


ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-69-4

75-71-8


76-13-1

76-14-2

76-15-3

25323-89-1

NTIS/OTS0000704


EPA/OTS; Doc #FYI-OTS-0789-0704

1989 –

STUDIES AND DOCUMENTS FUNDED BY THE CHEMICAL MANUFACTURE ASSOCIATION


FLUOROCARBON PANEL WITH ATTACHMENTS AND COVER LETTER DATED
08-21-89

Keywords:

CHEM MANUF ASSOC
FLUOROCARBON
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:



56-23-5

75-01-4

75-09-2

75-43-4

75-45-6


75-69-4

75-71-8



79-01-6

127-18-4

1320-37-2

10024-97-2

10102-43-9

10102-44-0

25323-89-1

26523-64-8

NTIS/OTS0520870

EPA/OTS; Doc #86-890000751



1989
– KITCHEN TEST ON
“FREON” REFRIGERANTS

WITH COVER SHEET AND LETTER DATED 05-05-89

HASKELL LABORATORIES

Keywords:

E I DUPONT DE NEMOURS & CO

DICHLOROMONOFLUOROMETHANE (75-43-4)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
GUINEA PIGS
INHALATION

CAS Registry Numbers:

75-43-4

75-45-6


75-71-8


75-72-9

75-73-0

76-13-1

9010-75-7

25989-16-6

NTIS/OTS0520347

EPA/OTS; Doc #86-890000908S

1989

– KITCHEN TESTS ON
“FREON” REFRIGERANTS

WITH COVER SHEET DATED
06-12-89 (SANITIZED)

Keywords:

CONFIDENTIAL
FREON 113 (76-13-1)
HEALTH EFFECTS
ACUTE TOXICITY
MAMMALS
GUINEA PIGS
INHALATION

CAS Registry Numbers:

75-43-4

75-45-6


75-46-7

75-71-8


75-72-9

75-73-0

76-13-1

76-19-7

2837-89-0

25989-16-6


NTIS/OTS0520188

EPA/OTS; Doc #86-890001045

1989

– MEMORANDUM REGARDING CHLOROFLUOROCARBON
OZONE DEPLETION EFFICIENCY
FC 22 VS FC 11 WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

CHLOROFLUOROCARBON OZONE
ENVIRONMENTAL FAT

CAS Registry Numbers:

75-45-6


75-69-4

75-71-8


NTIS/OTS0520189

EPA/OTS; Doc #86-890001046

1989

– POTENTIAL
STEADY-STATE OZONE DEPLETION FACTORS
WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

FLUOROCARBONS 113 (76-13-1)
ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-69-4

75-71-8

76-14-2

76-15-3

25323-89-1


NTIS/OTS0520192

EPA/OTS; Doc #86-890001049

1989

– MEMORANDUM REGARDING THE
RELATIVE OZONE DEPLETION POTENTIALS
FOR HALOCARBONS WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

METHYL CHLOROFORM (71-55-6)
ENVIRONMENTAL FATE

CAS Registry Numbers:

71-55-6

75-43-4

75-45-6


75-68-3

75-69-4

75-71-8

75-72-9

76-12-0

76-13-1

76-14-2

76-15-3

25323-89-1


NTIS/OTS0520193

EPA/OTS; Doc #86-890001050

1989

– MEMORANDUM REGARDING
FLUOROCARBON OZONE DEPLETION
POTENTIALS WITH ATTACHMENTS AND COVER LETTER DATED
07-10-89

Keywords:

E I DUPONT DE NEMOURS & CO

FLUOROCARBON OZONE
ENVIRONMENTAL FATE

CAS Registry Numbers:

75-45-6


75-69-4

75-71-8

76-13-1

76-14-2

76-15-3


NTIS/OTS0520130

EPA/OTS; Doc #86-890000986S

1985

– LETTER FROM E I DUPONT DE NEMOURS & COMPANY REGARDING RESULTS OF THE AIR SAMPLING SURVEY CONDUCTED
APRIL 10, 1985
WITH ATTACHMENT
(SANITIZED)

Keywords:

E I DUPONT DE NEMOURS & CO
FREON 22 (75-45-6)


HEALTH EFFECTS
INDUSTRIAL HYGIENE

CAS Registry Numbers:

75-45-6


NTIS/OTS0520128

EPA/OTS; Doc #86-890000984S

1984

– LETTER FROM E I DUPONT DE NEMOURS & COMPANY REGARDING RESULTS OF THE AIR SAMPLING SURVEY CONDUCTED SEPTEMBER 26,
1984
WITH ATTACHMENT
(SANITIZED)


Keywords:



E I DUPONT DE NEMOURS & CO


CHLORODIFLUOROMETHANE (75-45-6)
HEALTH EFFECTS
INDUSTRIAL HYGIENE


75-45-6


NTIS/OTS0557451

EPA/OTS; Doc #86940001155

1984


A NEW APPROACH TO THE ANALYSIS OF THE SUBSTITUTE HALOCARBONS IN ATMOSPHERIC SAMPLES, WITH COVER LETTER DATED
06/27/94

INTL SCIENCE CONSULTANTS

Keywords:

AFEAS
METHANE, DICHLORO-FLUORO- (75-43-4)
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

75-37-6

75-43-4

75-45-6


75-68-3

75-88-7

306-83-2

354-33-6

811-97-2

1649-08-7

1717-00-6

2837-89-0

NTIS/OTS0206128

EPA/OTS; Doc #878211389


1982
– ATMOSPHERIC TRACE GASES AT POINT BARROW AND
ARCTIC HAZE

OREGON GRADUATE CTR

Keywords:

DOW CHEM CO

METHYL CHLOROFORM (71-55-6)
ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

56-23-5

71-55-6

74-87-3

75-45-6


75-69-4

75-71-8


79-00-5

630-08-0

25323-89-1


NTIS/OTS0520227

EPA/OTS; Doc #86-890001085


1981

– F-22 MEASUREMENTS IN ATMOSPHERE
(FINAL REPORT)

Keywords:

CHEM MANUF ASSOC
CHLORODIFLUOROMETHANE (75-45-6)

ENVIRONMENTAL FATE
MONITORING

CAS Registry Numbers:

75-45-6


NTIS/PB81-143646, 21p

1978

– Health Hazard Evaluation Determination Report No. 78-8-534,
Chilton Metal Products, Chilton, Wisconsin

Authors: Bryant CJ


National Inst. for Occupational Safety and Health, Cincinnati, OH. Health Hazard and Technical Assistance Branch.

TD3: Environmental and medical surveys were conducted on December 14, 1977, April 18 to 20, 1978, and May 18, 1978, to evaluate employee exposure to potentially toxic substances at Chilton Metal Products (SIC-3291) in Chilton, Wisconsin. The evaluation was requested by an authorized employee representative on behalf of the 300 affected employees. Carbon monoxide (630080) concentrations ranged from 41 to 118 parts per million (ppm) for short term detectors and from 25 to 106ppm for long term detectors, exceeding the 50ppm OSHA standard.

Chlorodifluoromethane (75-45-6) (Freon-22) concentrations ranged from 2,906 to 3,146ppm, exceeding the American Conference of Governmental Industrial Hygienist standard of 1000ppm.
All other environmental samples were below their respective criteria. The author concludes that workers are exposed to hazardous concentrations of carbon monoxide. The Freon-22 concentrations present a potential exposure hazard. The author recommends that exposure to carbon monoxide be reduced

Keywords:

Hazardous materials
Industrial medicine
Toxic substances
Occupational safety and health


75-45-6

8 1 2 6 75 45

Sumber: https://www.fluoridealert.org/wp-content/pesticides/chlorodifluoro.ntis.htm

Baca :   Bangun Ruang Yang Tidak Memiliki Rusuk Adalah

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